A super high-rise project in Zhuhai has two towers,the apartment tower is 148.9m high,and it has the characteristics of high aspect ratio of core tube,weak wind resistance lateral stiffness and expansion of building façade,the office tower is 249.5m high,and it has the characteristics of expansion of building facade and core tube retraction in the middle and upper height area.In view of the difficulties in the structural design process,for the apartment building,the concrete strengthened beams were used in the refuge layers to improve the lateral stiffness of the structure effectively,the variable section columns were used to transfer the vertical force and the building façade.For the office building,the inclined columns were used to realize the transition of column position and the requirement of elevation.In order to reduce the influence of sudden change of stiffness caused by the core barrel retracting,the measures were taken to gradually retract the core tube in the middle area and to strengthen the corner wall limb after further retract the core tube in the high area.The elastic and elastoplastic checking results show that the structure meets the requirements of class C of the expected seismic performance target,it has good seismic performance and lateral stiffness,the structural measures are reasonable and reliable.