A simple and convenient synthesis of pyrrolo[3,4-b]quinolin-1-one derivatives
A simple and concise construction of a series of new quinoline-based isoindolin-l-ones,namely N-substituted-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-ones,wherein the benzene moiety of isoindolin-l-one is replaced by a quinoline ring has been achieved via a two-step procedure,involving the one-step synthesis of ethyl 2-chloromethyl-quinoline-3-carboxylate followed by its one-pot reaction with various amines in a refluxing EtOH-AcOH(v/v,10:1)solvent system.These newly synthesized compounds could be good candidates for the development of lead compounds for use in medicinal chemistry.
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