Early warning value and model construction of laboratory indexes of patients with hemorrhagic fever with renal syndrome to severe patients
Objective To analyze the early warning value of laboratory examination on admission of patients with hemorrhagic fever with renal syndrome to critically ill patients.Meetods In this study,a retrospective case-control study was used to analyze the clinical data and laboratory examination results of patients with hemorrhagic fever with renal syndrome admitted to the emergency department of Tangdu Hospital of Air Force Medical University from January 2021 to January 2022.According to the patient's laboratory indexes and clinical symptoms,the patients were divided into mild,moderate,severe and critical groups.The general data of the two groups were compared,and the independent risk factors of critically ill patients were screened by multi-factor logistic regression analysis,the predictive model of severe HFRS patients was constructed,and the ROC curve was drawn..Results Of the 164 patients with HFRS,50 were in the severe group and 114 in the mild group.The serum levels of WBC,AST,ALT,Cr,BUN,DD and PCT in the severe group were higher than those in the mild group,while the levels of PLT,ALB and PTA in the severe group were lower than those in the mild group.Multiple logistic regression analysis showed that WBC,PLT and PCT were independent influencing factors for the progression of critically ill patients.The predictive model of severe HFRS was established as follows:logit(P)=-0.321+0.040 WBC(×109/L)-0.045 PLT(×109/L)+0.086 PCT(ng/mL).The early warning efficacy of WBC,PLT,And PCT for severe HFRS was further analyzed.The area under the ROC curve(area under curve,AUC)was 0.779,0.842,0.862,and the optimal threshold was 10.435×109/L,41.5 ×109/Land 2.97 ng/mL,respectively.The AUC of joint detection is 0.900,the sensitivity is 88.0％,and the specificity is 82.5％,which is better than that of a single laboratory..Conclusions HFRS laboratory indexes have certain clinical significance for the identification of critically ill patients,in which serum WBC,PLT and PCT indexes are the risk factors of severe HFRS,which provides a theoretical basis for clinical diagnosis,treatment and prognosis of severe HFRS patients.
hemorrhagic fever with renal syndromelaboratory indexEarly warning value
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