Objective To investigate the effect of Early infarct growth rate(EIGR)on the prognosis of patients with acute large vessel occlusive ischemic stroke.Methods A total of 164 patients with acute large vessel occlusive ischemic stroke were enrolled in the emergency department of the First Affiliated Hospital of Nanjing Medical University from January 1,2020 to December 31,2022.According to the change of the National Institutes of Health Stroke Scale(NIHSS)score at admission and 72 h after treatment,the patients were divided into good prognosis group and poor prognosis group.The basic clinical data of the two groups were observed and compared.The risk factors of poor prognosis were analyzed by univariate regression.The effect of EIGR on prognosis after age stratification was further analyzed.Results Comparing the clinical data of the two groups,there was no difference in EIGR(mL/h)(7.67 vs.8.24,P=0.211)between the two groups.The product between EIGR and age was included as the interaction term,and the result of the interaction term in the model was statistically significant(OR=1.002,95％CI:1.000-1.003,P=0.032).Moreover,the result was still statistically significant after adjusting for relevant variables(gender,history of hypertension,history of atrial fibrillation,history of diabetes,history of coronary heart disease,and history of stroke)(OR=1.002,95％CI:1.000-1.003,P=0.027).Subgroup analysis was performed according to the median age(71 years).In the elderly group,the proportion of poor prognosis was higher with fast core infarction growth rate defined by 25 mL/h and 15 mL/h(P＜0.05).In the younger age group,there was no significant difference in the proportion of poor prognosis in the fast core infarction growth rate compared with the slow type(P＞0.05).Conclusions EIGR can predict the early clinical outcome early in elderly patients with large vessel occlusive ischemic stroke.
维普
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