Objective To summarize and analyze the modalities and experience of retrograde distal perfusion with distal perfusion catheter(DPC)via cannulation of the posterior tibial artery in veno-arterial extracorporeal membrane oxygenation(V-A ECMO).Methods The clinical data of 15 patients who were treated with V-A ECMO and underwent DPC placement via the posterior tibial artery in our hospital from January 2022 to June 2023 were retrospectively analyzed.Results The V-A ECMO catheterization method in 15 patients was percutaneous puncture catheterization,and all of them underwent surgical incision to indwelling retrograde DPC through the posterior tibial artery:6 cases of preventive catheterization,9 cases of remedial catheterization,the success rate of one-time catheterization was 93.33%,and the type of catheter was mainly 6 F sheath(66.67%).There was no ALI in preventive catheterization,and one case of osteofascial compartment syndrome occurred in remedial catheterization,and the catheterization time was(20.73±3.47)min.Conclusions In V-A ECMO,placement of DPC via the posterior tibial artery for retrograde distal perfusion is perfectly feasible,and has a high success rate,which can prevent or treat lower extremity ischemia.