极早产儿支气管肺发育不良相关肺高压合并动脉导管未闭9例预后分析
Prognosis of very preterm infants with bronchopulmonary dysplasia-associated pulmonary hyperten-sion and patent ductus arteriosus:An analysis of 9 cases
锡洪敏 1马丽丽 1尹向云 1杨萍 1姜红 1李向红1
作者信息
- 1. 青岛大学附属医院新生儿科,山东青岛 266555
- 折叠
摘要
目的 分析9例支气管肺发育不良(bronchopulmonary dysplasia,BPD)相关肺高压(pulmonary hy-pertension,PH)合并动脉导管未闭(patent ductus arteriosus,PDA)极早产儿行PDA结扎术后的临床转归.方法 回顾性分析9例合并PDA的BPD相关PH的极早产儿临床资料,所有患儿均给予PDA结扎手术,术后规律随访.结果 手术治疗后7例患儿肺动脉压力降至正常,顺利脱机并出院,且后期规律门诊随访,均随访至2022年6月.随访者中最大者已4岁,所有患儿心脏超声示心脏结构及功能、肺动脉压力均正常,生长发育正常,无反复呼吸道感染发生.2例患儿死亡.结论 合并PDA的BPD相关PH的极早产儿病情危重,在药物治疗失败的情况下,PDA适时结扎是改善预后的手段.
Abstract
Objective To investigate the clinical outcome of 9 very preterm infants with bronchopulmonary dysplasia(BPD)-associated pulmonary hypertension(PH)and patent ductus arteriosus(PDA)after PDA ligation.Methods A retrospec-tive analysis was performed for the clinical data of 9 very preterm infants with BPD-associated PH and PDA,and all infants under-went PDA ligation and were followed up regularly after surgery.Results After surgical treatment,7 infants had normal pulmo-nary artery pressure and were discharged after successful ventilator weaning,and all these infants were regularly followed up to June 2022 at the outpatient service,among whom the oldest infant was aged 4 years;echocardiography showed that all infants had normal heart structure and function,pulmonary artery pressure,and growth and development,without recurrent respiratory infec-tion.Two infants died.Conclusion Very preterm infants with BPD-associated PH and PDA often have critical situations,and in case of failed pharmacotherapy,timely PDA ligation is an important method to improve prognosis.
关键词
支气管肺发育不良/动脉导管未闭/肺动脉高压/结扎术/预后/婴儿,极度早产Key words
Bronchopulmonary dysplasia/Ductus arteriosus,patent/Pulmonary arterial hypertension/Ligation/Prog-nosis/Infant,extremely premature引用本文复制引用
基金项目
青岛大学附属医院"临床医学+X"科研项目(QD-FY+2021013)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据