1型糖尿病儿童青少年血清25-羟维生素D3与糖化血红蛋白水平的关系
Relationship between serum 25-hydroxyvitamin D3 levels and glycosylated hemoglobin levels in chil-dren and adolescents with type 1 diabetes mellitus
许东伟 1刘洋 2王丽娜 1田飞 1赵岩 3陈志红1
作者信息
- 1. 青岛大学附属医院儿童内分泌消化科,山东青岛 266003
- 2. 青岛大学医学部
- 3. 临沂市平邑县人民医院儿科
- 折叠
摘要
目的 分析1型糖尿病(type 1 diabetes mellitus,TIDM)儿童青少年血清25-羟维生素D3[(25-(OH)D3]水平,探讨其与糖化血红蛋白(HbA1c)水平的关系.方法 收集2016年1月-2021年12月就诊于青岛大学附属医院儿童内分泌消化科的T1DM儿童青少年129例,设为T1DM组;根据HbA1c水平将T1DM组分为两亚组:血糖控制良好组(A组,HbA1c＜7.5％)和血糖控制不良组(B组,HbA1c≥7.5％).收集健康儿童青少年33例,设为对照组.收集所有入组儿童青少年的一般临床资料,检测其血清钙、磷、25-(OH)D3、HbA1c水平.结果 T1DM组儿童青少年BMI及血清钙、磷和25-(OH)D3水平显著低于对照组(t=-15.665～-3.679,P＜0.05),A组血清25-(OH)D3水平明显高于B组(t=3.857,P＜0.05),二元logistic回归分析显示,25-(OH)D3水平降低是T1DM儿童青少年血糖控制不良的危险因素(OR=1.141,95％CI=1.051～1.239,P＜0.05).结论 T1DM儿童青少年血清25-(OH)D3水平低于健康青少年,且血糖控制不佳可能与血清25-(OH)D3水平降低有关;T1DM儿童青少年应该适当补充维生素D,并加强其血糖管理.
Abstract
Objective To investigate the serum levels of 25-hydroxyvitamin D3[25-(OH)D3]in children and adolescents with type 1 diabetes mellitus(T1DM),and to investigate the relationship between 25-(OH)D3 levels and glycosylated hemoglobin(HbA1c)levels.Methods We included 129 children and adolescents with T1DM who visited the Department of Pediatric Endo-crinology,Metabolism Gastroenterology of The Affiliated Hospital of Qingdao University from January 2016 to December 2021(T1DM group).They were divided into two subgroups according to HbA1c levels:patients with good glycemic control(group A,HbA1c＜7.5％)and those with poor glycemic control(group B,HbA1c≥7.5％).Thirty-three healthy children and adolescents were selected as control group.The general data and serum calcium,phosphorus,25-(OH)D3,and HbA1c levels of the subjects were collected.Results The T1DM group showed a significantly lower body mass index and significantly lower serum calcium,phosphorus,and 25-(OH)D3 levels than the control group(t=-15.665--3.679,P＜0.05).The 25-(OH)D3 level in group A was significantly higher than that in group B(t=3.857,P＜0.05).The binary logistic regression analysis showed that decreased 25-(OH)D3 levels were a risk factor for poor blood sugar control in children and adolescents with T1DM(OR=1.141,95％CI=1.051-1.239,P＜0.05).Conclusion Children and adolescents with T1DM have decreased 25-(OH)D3 levels compared with healthy children and adolescents,and the decrease may be closely related to poor blood glucose control.It is necessary for children and adolescents with T1DM to supplement vitamin D and strengthen blood glucose management.
关键词
糖尿病,1型/维生素D缺乏/糖基化血红蛋白A/骨化二醇/钙Key words
Diabetes mellitus,type 1/Vitamin D deficiency/Glycated hemoglobin A/Calcifediol/Calcium引用本文复制引用
基金项目
青岛市科技局科研项目(18-6-1-73-nsh)
出版年
2024
国家科技期刊平台
NSTL
万方数据