Relationship between serum 25-hydroxyvitamin D3 levels and glycosylated hemoglobin levels in chil-dren and adolescents with type 1 diabetes mellitus
Objective To investigate the serum levels of 25-hydroxyvitamin D3[25-(OH)D3]in children and adolescents with type 1 diabetes mellitus(T1DM),and to investigate the relationship between 25-(OH)D3 levels and glycosylated hemoglobin(HbA1c)levels.Methods We included 129 children and adolescents with T1DM who visited the Department of Pediatric Endo-crinology,Metabolism Gastroenterology of The Affiliated Hospital of Qingdao University from January 2016 to December 2021(T1DM group).They were divided into two subgroups according to HbA1c levels:patients with good glycemic control(group A,HbA1c＜7.5％)and those with poor glycemic control(group B,HbA1c≥7.5％).Thirty-three healthy children and adolescents were selected as control group.The general data and serum calcium,phosphorus,25-(OH)D3,and HbA1c levels of the subjects were collected.Results The T1DM group showed a significantly lower body mass index and significantly lower serum calcium,phosphorus,and 25-(OH)D3 levels than the control group(t=-15.665--3.679,P＜0.05).The 25-(OH)D3 level in group A was significantly higher than that in group B(t=3.857,P＜0.05).The binary logistic regression analysis showed that decreased 25-(OH)D3 levels were a risk factor for poor blood sugar control in children and adolescents with T1DM(OR=1.141,95％CI=1.051-1.239,P＜0.05).Conclusion Children and adolescents with T1DM have decreased 25-(OH)D3 levels compared with healthy children and adolescents,and the decrease may be closely related to poor blood glucose control.It is necessary for children and adolescents with T1DM to supplement vitamin D and strengthen blood glucose management.
Diabetes mellitus,type 1Vitamin D deficiencyGlycated hemoglobin ACalcifediolCalcium
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