In insects,the determination of sex involves a sophisticated mechanism governed by alternative splicing,which allows for a coexistence of conservatism and diversity.The rapid evolution of upstream sex determination primary signals leads to significant morphological,physiological,and behavioral differences between individuals of the two sexes,despite sharing nearly identical genomes.Conversely,the downstream gene doublesex exhibits a high degree of conservation in both structure and function.This article reviews the mechanistic role of primary signals in regulating sex determination in insects,summarizes the response mechanisms of downstream signaling pathways,and introduces the conserved gene doublesex as a key player in sex determination.The aim is to provide new insights for a deeper understanding of the mechanisms underlying insect sex determination and contribute to novel perspectives in the context of agricultural pest control.
Sex determinationprimary signaldoublesexalternative splicing
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