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刺激响应型智能纳米递药系统的研究进展

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开发高效、绿色农药制剂以最大限度地减少化学残留和环境污染,对于确保粮食和生态安全至关重要.纳米技术的发展为农业绿色农药制剂的创制提供了策略,科研人员设计了一系列针对病虫草害引发的病理环境和体外物理刺激的智能响应型金属或无机纳米载体,该类载体可以通过响应动植物体内pH、活性氧(reactive oxygen species,ROS)、氧化还原条件等内源性变化或者温度、光照等外部刺激,来实现药物的精准可控释放,并提高对病虫草害的防治效率.本文从内源性刺激响应、外源性刺激响应和多重刺激响应3个方面综述了当前农业领域智能响应型纳米递药系统的研究进展,对智能响应型纳米递药系统的功能设计、作用特点及效果进行了介绍,以期为农药/核酸类药物及其递送系统的研究提供参考.未来智能响应型纳米递药系统将会作为一种有前途的方式,提高药剂的利用率,实现药剂的靶向释放.
Research advances of stimuli-responsive intelligent nanodrug delivery systems
Developing efficient and environmentally friendly pesticide formulations to minimize chemical residues and pollution to the greatest extent possible is critical to ensure food and ecological security.The development of nanotechnology has provided strategies for the creation of green pesticide formulations in agriculture.Researchers have developed a series of intelligent responsive metal or inorganic nanocarriers that target pathological environments and in vitro physical stimuli from diseases,pests and weeds.These carriers can achieve precise-controllable drug release by responding to endogenous changes in animals and plants such as pH,reactive oxygen species(ROS)and redox conditions,or external stimuli such as temperature and light,and improve the efficiency of disease,pest and weed control.From three aspects of responding to endogenous stimuli,responding to exogenous stimuli and responding to multiple stimuli,in this article we reviewed the current status of research on intelligent responsive nano-based drug delivery systems in the agricultural field,introduced the functional design,functional characteristics,and effects of intelligent responsive nanocarriers to serve as a reference for research on pesticides/nucleic acid drugs and their delivery systems.In the future,intelligent responsive nanodrug delivery systems could be a promising vehicle to enhance drug utilization and realize target-specific drug release.

Nanodrug delivery systemintelligent responseprecise-controllable releaseendogenous stimuliexogenous stimulimultiple stimuli

王晓迪、雷可心、郭建洋、杨念婉、万方浩、吕志创、刘万学

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中国农业科学院植物保护研究所,植物病虫害综合治理全国重点实验室,北京 100193

中国农业科学院西部农业研究中心,昌吉 831100

纳米递药系统 智能响应 精准可控释放 内源性刺激 外源性刺激 多重刺激

国家重点研发计划项目国家重点研发计划项目国家重点研发计划项目天山英才青年科技拔尖人才专项国家自然科学基金项目

2021YFC26004002021YFD14002002022YFC26010002022TSYCCX008432072494

2024

10.16380/j.kcxb.2024.09.011

昆虫学报
中国科学院动物研究所,中国昆虫学会

昆虫学报

CSTPCD北大核心
影响因子：0.756
ISSN：0454-6296
年,卷(期)：2024.67(9)