On the basis of PWR physical characteristics and the integrated use of neutron kinetics, temperature feedback effect, poisoning effect, core heat transfer and other related mathematics model, the nuclear power station's core physical and mathematical models applicable to a PC simulation has been established. Then the real-time simulation model, which including Neutron Dynamics simulation module, Xenon Poisoning Effects simulation module, Temperature Feedback simulation module and Core Heat Transfer simulation module, is realized by the Matlab / Simulink simulation tool. Finally they are integrated into nuclear power plant Reactor System simulation module. Simulation results show that the mathematical models have high degree of accuracy. The model can be used to analyze the most transient reactor process, explain neutron flux density properties with time, and research the partial perturbation's influence to reactor parameters.