激素类药物醋酸地塞米松纳米粒的制备及其质量评价
Development and Evaluation of Hormone Nanoparticles of Dexamethasone Acetates
摘要
以单硬脂酸甘油酯为载体,应用乳化-溶剂挥发法制备醋酸地塞米松纳米粒,测定其粒径、药物包封率等性质。经过正交优化试验确定其优选方案为：载体材料单硬脂酸甘油酯的用量为0.3g,表面活性剂为硬脂酸聚烃氧酯（S-40）/泊洛沙姆（F68）（质量比为7/3）的混合物,有机相氯仿与水相的体积比为5：75,蒸发有机相氯仿时的真空度为0.05MPa。制备所得的醋酸地塞米松纳米粒球体均匀度好,平均粒径在100nm左右,载药纳米粒的包封率在89.03%左右。
Abstract
Monostearin as carrier, Dexamethasone acetates nanoparticles were prepared by the emulsion-solvent evaporation method and investigated their size and encapsulation efficiency. Various preparation processes of Dexamethasone acetates nanoparticles were carr
关键词
醋酸地塞米松/纳米粒/单硬脂酸甘油酯/包封率Key words
Dexamethasone acetates/Nanoparticles/Monostearin/Encapsulation efficiency引用本文复制引用
出版年
2011
NETL
NSTL
万方数据