An interior detection alarm of temperature and gas for vulnerable groups has been introduced in this paper. The zirconia sensor and temperature sensor DS18B20 has been used to detect interior temperature and oxygen concentration in real time. By process-ing of MCU AT89C51,judging if danger happens. It will alarm via buzzer and LED light-groups, and display the distress signal via monitor LM016L. The system has the characteristics of small size, stable performance, easy to operate. It is suitable for family car and school bus.