This study takes listed companies in pharmaceutical manufacturing industry as the research object to analyze the influencing factors of enterprise cost stickiness.Based on the perspective of configuration,fuzzy set qualitative comparative analysis(fsQCA)was used to explore the synergistic and joint effects of five antecedent conditions on the cost stickiness of listed companies in the pharmaceu-tical manufacturing industry,and explore the path to form cost stickiness.The results show that capital structure,ownership concentra-tion,R&D investment intensity,internal control quality and macroeconomic environment are not the necessary conditions to affect the cost stickiness of enterprises,but the cost stickiness is the result of multiple antecedent conditions.The path of forming high cost stick-iness can be summarized into three types:equity structure-macro-economic environment synergistic type,capital structure-equity struc-ture synergistic type,and capital structure-R&D investment intensity synergistic type.There are three paths forming non-high cost vis-cosity,which are asymmetrical with the path with high cost viscosity.