Metro is the main modes of transportation in GuangZhou which is a densely populated city. This essay introduced the current situation about operation and management system of GuangZhou metro, meanwhile gave the statistical analysis of the major accident happend in GuangZhou metro system since 2011, especially pointed out the main cause of the subway safety accident. In this essay, we also put forward concrete suggestions for those problems which provides a case can be used for reference to improve the safety level of urban rail traffic engineering construction in our country.