Ultrasound is a physical process has been used for sludge cell rupturing.The method has advantages of simple operation,sludge distintegration speed,wide application range,will not cause secondary pollution to the environment.This study was based on ultrasonication equipment used for pretreatment thickened waste activated sludge.The experimental was observed the change of floc structure,COD,TN and TP at different ultrasonic time.As a result,the ultrasonic rupture the cell wall in evidence and facilitate the release of intracellular matter to the aqueous phase.The COD,TN and TP release was proportion of sonication duration.