Clinical characteristics and pregnancy outcomes of pregnancy-associated fulminant type-1 diabetes
Objective To analyze the clinical characteristics and pregnancy outcomes of pregnancy-associated fulminant type-1 diabetes.Methods The clinical data of 43 patients with pregnancy-associated fulminant type-1 diabetes collected from domestic and foreign databases,and of 5 patients from our hospital was included for analysis.Results The majority(62.5％)of patients had onset of symptoms in the third trimester of pregnancy.Gastrointestinal symptoms and hyperglycemic symptoms were common.Eight cases(16.7％)of live birth were reported,There is no statistically significant difference in live birth rates between domestic and international patients.The average interval between onset and treatment was 0.50 for foreign patients,compared with 2.19 for domestic ones with a significant difference(t=2.060,P=0.045).Meanwhile,no significant difference was observed in results of laboratory tests,such as glucose levels,blood sodium or potassium concentrations(P＞0.05).However,there was significant difference in the onset of gestational age between patients with live birth and those with fetal loss(35.17 weeks vs.32.54 weeks,t=2.076,P=0.047).There is no statistically significant difference between other clinical features.Conclusion Patients with pregnancy-associated fulminant type-1 diabetes are likely to present with various clinical manifestations,which rapidly progress to critical illness with a high percentage of fetal loss.Obstetricians should be alert to this risk in order to improve maternal and neonatal outcomes through early intervention.
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万方数据
