Clinical features and therapeutic effect in primary stage Ⅰ/ⅡE upper aerodigestive tract extranodal NK/T cell lymphoma
Objective To investigate the clinical features of and curative effect against upper aerodigestive tract extranodal natural kill T-cell lymphoma(UAT-ENKTCL).Methods The clinical data of primary stage Ⅰ/ⅡE UAT ENKTCL patients admitted to General Hospital of PLA between June 2009 and June 2020 was analyzed retrospectively,including clinical characteristics,approaches,regimens and efficacy.Results Sixty-one patients were enrolled.Treatment strategies were chemotherapy alone and chemotherapy followed by radiotherapy.The complete remission(CR)rate was 62.5％and 82.2％(x2=1.714,P=0.190).The chemotherapy regimens involved the anthracycline group,anthracycline combined with L-asparaginase group and the non-anthracycline combined with asparaginase group.The corresponding CR rate was 46.7％,72.7％,91.7％(x2=91.155,P＜0.001),5-year OS rate was 46.7％,68.2％,94.4％(x2=9.893,P=0.007),and 5-year PFS rate was 33.3％,63.6％,79.7％(x2=8.575,P=0.014)in the three groups.The therapeutic effects of the non-anthracycline combined with asparaginase group were superior to the other two groups and the differences were statistically significant(P=0.007,0.005,0.002,0.004).Conclusion The chemotherapy regimen for primary stage Ⅰ/ⅡE UAT-ENKTCL patients based on non anthracycline combined with L-asparaginase regimens can significantly improve the efficacy.
NK/T cell lymphomaPrimary upper respiratory and digestive tractChemotherapy regimenEfficacy
NETL
NSTL
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