Elevated tumor markers and related factors in healthy physical examinees
Objective To investigate the incidence and related factors of elevated tumor markers in healthy physical examinees.Methods Related data was retrieved from the electronic medical record of healthy personnel who had undergone physical examinations between 2017 and 2021 in our sanatorium.Cases of positive tumor markers were followed up before changes in tumor markers and related factors were analyzed.Results The rate of elevated tumor markers was generally on the rise,and the differences were of statistical significance from 2017 to 2021(x2=1 404.894,P＜0.001).There were significant differences in the overall distribution of elevated tumor markers between patients with prostate cancer,liver cancer or pancreatic cancer(x2=47.556,16.867,24.100,all P＜0.001).The top five elevated tumor markers were CA724,CEA,CA125,SCC,CA199.Multivariate logistic regression analysis showed that age and high density lipoprotein cholesterol were the risk factors for elevated tumor markers(OR=1.023,1.411,P=0.032,0.037),while being female,red blood cell count and collagen Ⅳ were protective factors against elevated serum tumor markers(OR=0.386,0.654,0.983,P＜0.001,=0.002,＜0.001).Conclusion The incidence of elevated tumor markers in healthy people is getting increasingly high,so tumor markers screening via regular health checkups is necessary.In order to fend off tumor-related diseases,screening for tumor diseases is recommended in the annual physical examination for pilots.
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