The predictive value of inhibin-A versus traditional biochemical indices in preeclampsia
Objective To assess the potential role of routine blood,coagulation,and thyroid function indices as well as inhibin A(INH-A)levels in predicting the risk of preeclampsia(PE).Methods A retrospective analysis was performed of 120 pregnant women who had delivered in Beijing Chaoyang District Maternal and Child Health Hospital between July 2017 and July 2019,including 60 PE patients(experimental group)and 60 healthy pregnant women(control group).Blood routine,coagulation,thyroid function indexes,and INH-A levels in both groups were collected and analyzed.Independent samples t-test,logistic regression analysis,and receiver operating characteristic(ROC)curve analysis were applied to assess the predictive value of these indicators for PE.Results White blood cell(WBC)count and mean platelet volume(MPV)were significantly higher in the experimental group than in the control group(t=2.982,2.236,P=0.007,＜0.001),but prothrombin time(PT)and activated partial thromboplastin time(APTT)were significantly shorter(t=0.759,13.780,both P＜0.001).The levels of thyroid stimulating hormone(TSH)and INH-A in the experimental group were higher than in the control group,while the free thyroxine(FT4)level was lower,and the differences were statistically significant(t=5.067,8.888,2.657,all P＜0.001).The results of multiple logistic regression analysis showed that MPV(OR=3.574,95%CI:1.230～10.389,P=0.019),TSH(OR=12.731,95%CI:1.565～103.545,P=0.017),and INH-A(OR=1.020,95%CI:1.003～1.038,P=0.024)were risk factors for PE,while APTT(OR=0.263,95%CI:0.109～0.634,P=0.003)was a protective factor for PE.The area under the ROC curve for MPV was 0.794,with a sensitivity of 0.650 and a specificity of 0.500 when 10.210fl was used as the cut-off value.The area under the ROC curve for APTT was 0.974,with a cut-off value of 32.185s as the cut-off value,and the sensitivity was 0.933 and the specificity was 0.883.The area under the ROC curve for TSH was 0.853,and the sensitivity was 0.900 and the specificity was 0.550 with 3.330 mIU/L as the cut-off value.The optimal cut-off value of INH-A was 758.50 pg/mL,with a sensitivity of 0.733 and a specificity of 0.917.Conclusion MPV,PT,TSH,and INH-A levels are closely associated with the development of PE and can be used as early predictive biomarkers for PE.This study provides biological data for clinical prediction and intervention of PE.
万方数据
维普
