首页|巨噬细胞极化在部分血栓性疾病中的作用

巨噬细胞极化在部分血栓性疾病中的作用

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血栓性疾病是指因血液在血管内异常凝固形成血栓,从而引起一系列临床症状的疾病总称,包括下肢深静脉血栓形成、脑卒中、动脉粥样硬化、糖尿病等疾病.血栓形成是一个复杂的、循序渐进的过程,大致可概括为血管内皮损伤暴露、内源性凝血系统启动、血小板黏附聚集、纤维蛋白网生成、血细胞淤积等过程.在此过程中,巨噬细胞发挥了重要作用.它们通过参与局部的炎症反应,调控血栓的形成和消退.巨噬细胞极化是近年来的研究热点,它主要指巨噬细胞在不同环境刺激下发生形态和功能上的变化.巨噬细胞极化可分为经典型(M1 型)、替代型(M2 型)以及一些特殊的极化状态.巨噬细胞极化状态的转变在免疫应答、病原体感染、肿瘤免疫和自身免疫等过程中具有重要作用.综述巨噬细胞极化在血栓性疾病中的调控关系,为血栓性疾病的治疗提供新的方向.
The Role of Macrophage Polarization in Thrombotic Diseases
Thrombotic diseases refer to a group of conditions characterized by abnormal blood coagulation within blood vessels,leading to the formation of blood clots and a series of clinical symptoms.This includes diseases such as deep vein thrombosis in the lower extremities,stroke,atherosclerosis,and diabetes.Thrombosis is a complex,progressive process that can be broadly summarized as the exposure of vascular endothelial damage,activation of the intrinsic coagulation system,platelet adhesion and aggregation,fibrin network formation,blood cell stasis.Macrophages play an important role in this process.They are involved in local inflammatory responses,regulating both the formation and resolution of thrombi.Macrophage polarization is a hot research topic in recent years,which mainly refers to the morphological and functional changes of macrophages in response different environmental stimuli.Macrophage polarization can be classified into classical(M1)and alternative(M2)types,as well as several specialized polarization states.The transition of macrophage polarization states plays an important role in immune responses,pathogen infections,tumor immunity,and autoimmune processes.This review discusses the regulatory relationship of macrophage polarization in thrombotic diseases,providing new directions for the treatment of these conditions.

Thrombotic diseasesDeep vein thrombosisMacrophagesMacrophage polarization

申屠昊鹏、杨菁、葛卫清、周涛、宋恩

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昆明医科大学第一附属医院运动医学科,云南 昆明 650032

血栓性疾病 深静脉血栓 巨噬细胞 巨噬细胞极化

2025

昆明医科大学学报
昆明医学院

昆明医科大学学报

影响因子:0.829
ISSN:1003-4706
年,卷(期):2025.46(1)