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儿童肥胖症中IGF-1和IGFBP-3的水平及诊断价值

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目的 探讨IGF-1 和IGFBP-3 在儿童肥胖症中的表达变化及诊断价值.方法 血液样本和对应的临床信息来源于 2023 年 12 月至 2024 年 3 月期间就诊于昆明市儿童医院的人群,设置对照组(健康儿童;n=115)和研究组(肥胖症儿童;n=86).采用ELISA法检测两组血清中IGF-1 和IGFBP-3 的水平.收集两组的临床资料,分析IGF-1 和IGFBP-3 与临床资料的相关性及在儿童肥胖症中的诊断价值.结果 相较于对照组,研究组中体重和BMI显著增加(P<0.001),IGF-1 和IGFBP-3 显著降低(P<0.05).IGF-1 水平与总胆固醇、甘油三酯、载脂蛋白B和胰岛素抵抗指数呈现负相关(P<0.05),与载脂蛋白A和空腹胰岛素呈现正相关(P<0.05);IGFBP-3 表现出相反的模式(P<0.05).ROC诊断曲线显示,IGF-1 和IGFBP-3 的曲线下面积为 0.598和 0.665.结论 IGF-1 和IGFBP-3 在儿童肥胖症中低表达,并且与肥胖指标相关,具有一定的诊断价值.
Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value
Objective To explore the expression changes of IGF-1 and IGFBP-3 in childhood obesity and their diagnostic value.Methods Blood samples and corresponding clinical information were collected from patients attending Kunming Children's Hospital from December 2023 and March 2024,and were divided into a control group(healthy children;n=115)and a study group(obese children;n=86).Serum levels of IGF-1 and IGFBP-3 in both groups were measured by using ELISA.Clinical data from both groups were analyzed to assess the correlation between IGF-1 and IGFBP-3 and clinical information,as well as their diagnostic value in childhood obesity.Results Compared to the control group,the study group exhibited a significant increase in weight and BMI(P<0.001)while IGF-1 and IGFBP-3 levels were significantly lower(P<0.05).IGF-1 levels exhibited a negative correlation with total cholesterol,triglycerides,apolipoprotein B,and insulin resistance index(P<0.05),and a positive correlation with apolipoprotein A and fasting insulin(P<0.05);IGFBP-3 displayed the opposite pattern(P<0.05).ROC diagnostic curves indicated that the area under the curve for IGF-1 and IGFBP-3 was 0.598 and 0.665,respectively.Conclusion IGF-1 and IGFBP-3 are expressed at low levels in childhood obesity and are associated with obesity indicators,demonstrating certain diagnostic value.

Childhood obesityDiagnosisIGF-1IGFBP-3

罗丽丝、杨清雄、王燕、刘四香、许榛、凌昱

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昆明市儿童医院儿保科,云南 昆明 650034

昆明市儿童医院放射科,云南 昆明 650034

昆明市儿童医院检验科,云南 昆明 650034

儿童肥胖症 诊断 IGF-1 IGFBP-3

2025

昆明医科大学学报
昆明医学院

昆明医科大学学报

影响因子:0.829
ISSN:1003-4706
年,卷(期):2025.46(1)