CD4+CD25+Treg、sCD30与淋巴瘤临床特征关系及预测化疗后感染价值
Correlations between CD4+CD25+Treg,sCD30 and Clinical Characteristics of Lymphoma and Their Value in Predicting Infection after Chemotherapy
刘春艳 1常炳庆 1李超 1任欣 1刘小琴1
作者信息
- 1. 北京航天总医院血液科,北京 100076
- 折叠
摘要
目的 探讨淋巴瘤患者外周血CD4+CD25+调节性T细胞(CD4+CD25+Treg)、可溶性CD30(sCD30)表达及意义.方法 选取 2018 年 1 月至 2022 年 12 月北京航天总医院收治的 83 例淋巴瘤患者作为研究对象,统计其外周血CD4+CD25+Treg、sCD30 表达,Spearman分析外周血CD4+CD25+Treg、sCD30 表达与骨髓浸润相关性,同时将研究对象根据利妥昔单抗化疗后有无感染分为感染组(n=26)和非感染组(n=57),比较两组外周血CD4+CD25+Treg、sCD30 表达及差值,绘制受试者工作特征曲线(ROC)及曲线下面积(AUC)分析预测效能.结果 研究组有骨髓浸润患者外周血CD4+CD25+Treg、sCD30 表达高于无骨髓浸润患者(P<0.05);淋巴瘤患者外周血CD4+CD25+Treg、sCD30 表达与骨髓浸润呈正相关(r=0.612、0.634,P<0.05);化疗后感染组外周血Tregs、sCD30 表达高于非感染组,差值高于非感染组(P<0.05);ROC曲线显示,外周血CD4+CD25+Treg、sCD30 差值联合预测淋巴瘤患者化疗后感染的 AUC为 0.916(0.834～0.965),优于单一预测.结论 淋巴瘤外周血CD4+CD25+Treg、sCD30 呈高表达,其值与骨髓浸润呈正相关,联检有助于提高化疗后感染预测效能,指导临床诊治.
Abstract
Objective To investigate the expression and significance of CD4+CD25+regulatory T cells(CD4+CD25+Treg)and soluble CD30(sCD30)in peripheral blood of lymphoma patients.Methods A total of 83 lymphoma patients admitted to Beijing Aerospace General Hospital from January 2018 to December 2022 were selected as the research subjects,and their peripheral blood CD4+CD25+Treg and sCD30 expressions were statistically analyzed.Spearman analysis was used to investigate the correlation between peripheral blood CD4+CD25+Treg and sCD30 expressions and bone marrow infiltration.At the same time,the research subjects were divided into an infection group(n=26)and a non-infection group(n=57)according to the presence or absence of infection after rituximab chemotherapy.The expressions and differences of peripheral blood CD4+CD25+Treg and sCD30 in the two groups were compared,and the receiver operating characteristic(ROC)curve and area under the curve(AUC)were used to analyze the predictive efficacy.Results The expression of CD4+CD25+Treg and sCD30 in peripheral blood of patients with bone marrow infiltration was higher than that of patients without bone marrow infiltration in the research group(P<0.05);the expression of CD4+CD25+Treg and sCD30 in peripheral blood of lymphoma patients was positively correlated with bone marrow infiltration(r=0.612,0.634,P<0.05);the expression of Tregs and sCD30 in peripheral blood of the infection group after chemotherapy was higher than that of the non-infection group,and the difference was higher than that of the non-infection group(P<0.05);the ROC curve showed that the combined prediction of the difference of CD4+CD25+Treg and sCD30 in peripheral blood for the infection after chemotherapy in lymphoma patients had an AUC of 0.916(0.834～0.965),which was superior to single prediction.Conclusion The high expression of CD4+CD25+Treg and sCD30 in peripheral blood of lymphoma patients is positively correlated with bone marrow infiltration.Combined testing can improve the predictive efficacy of infection after chemotherapy and guide clinical diagnosis and treatment.
关键词
淋巴瘤/骨髓浸润/化疗/感染/CD4+CD25+Treg/sCD30Key words
Lymphoma/Bone marrow infiltration/Chemotherapy/Infection/CD4+CD25+Treg/sCD30引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据