Objective:To study the effect of the depth of invasion(DOI)on predicting lymph node metastasis and evaluating prognosis in patients with early oral squamous cell carcinoma(OSCC).Methods:Patients with early OSCC from January 2015 to December 2017 were enrolled and evaluated for pathological DOI and lymph node metastasis.The DOI cutoff value of lymph node metastasis in OSCC was predicted by the area under curve(AUC)of the receiver operating characteristic(ROC)curve.Moreover,the difference of lymph node metastasis rate and survival curve among different DOI groups was compared.Results:Ninety four early OSCC patients were included,with the median follow-up age of 66 and median follow-up time of 35.5 months.Pathological metastasis-positive node were observed in 18 patients with the average DOI of 6.09 mm;the average DOI of others was 3.61 mm(P<0.05).The area under the ROC curve was 0.86,and the optimal DOI cutoff value was 4.41 mm(sensitivity 78%;specificity 84%).When DOI>4.41 mm,lymph node metastasis rate was higher,that is 14.89%vs 4.25%(P<0.05)and the median survival was shorter(41.4 months vs 52.6 months;HR:1.80,95%CI:0.88～3.69,P=0.10).Conclusion:DOI in early OSCC showed positive correlation with the lymph node metastasis rate.However,the prognosis of these patients was not apparently worse,indicating the index may not be an independent predictor for both lymph node metastasis and prognosis in early OSCC patients.
oral squamous cell carcinomadepth of invasionlymph node metastasisprognosis
国家科技期刊平台
NSTL
万方数据
维普
