Interpretation of the WHO 2022 classification of head and neck tumours(5th Edition):The epithelial tumours of oral cavity and mobile tongue
The 5th edition of the Classification of Head and Neck Tumours by the World Health Organization(WHO)was published in March 2022.In the section on oral cavity and mobile tongue tumours,the classification of epithelial tumours in the 5th edition has undergone several modifications compared to the 4th edition published in 2017.Notably,oral potentially malignant disorders(OPMD)and oral epithelial dysplasia(OED)have been addressed separately,and in-depth discussions have been included regarding submucosal fibrosis(SF)and human papillomavirus(HPV)-associated oral epithelial dysplasia(HPVOED).Additionally,the section on squamous cell carcinoma(SCC)now includes carcinoma cuniculatum(CC)and verrucous carcinoma(VC),emphasizing their distinctive clinical and histological characteristics.This review provides a comprehensive overview of the most recent advancements in clinical,histological,and molecular research on epithelial tumours of oral cavity and mobile tongue since 2017.
World Health Organizationoral cavity and mobile tongue tumoursnon-neoplastic lesionsepithelial tumours