免疫细胞对骨髓间充质干细胞成骨分化作用及机制的研究进展
Research progress on the effect and mechanism of immune cells on osteogenic differentiation of bone marrow mesenchymal stem cells
石琰 1郭昊 1郑凯娟 1杨镇鸣 1强金彪 1史册1
作者信息
- 1. 吉林大学口腔医院口腔病理科,吉林省牙发育及颌骨重塑与再生重点实验室,长春 130021
- 折叠
摘要
骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)在骨缺损修复和骨再生中的作用得到了广泛研究.许多证据表明,有效的内源性骨再生需要免疫系统的协调.在骨缺损愈合中,免疫细胞和BMSCs的相互作用是促进骨形成的关键.近年来的研究发现,多种免疫细胞通过释放的细胞因子和信号促进BMSCs的成骨向分化,从而利于骨缺损修复和骨再生,成为新的骨缺损修复治疗靶点.因此,本文就免疫细胞对BMSCs成骨作用及其相关机制的研究现状进行综述.
Abstract
The role of bone marrow mesenchymal stem cells(BMSCs)in bone defect repair and bone regeneration has been extensively studied.Much evidence suggests that effective endogenous bone regeneration requires coordination of the immune system.The interaction between immune cells and BMSCs is crucial to promoting bone formation in the healing of bone defects.In recent years,it has been found that a variety of immune cells promote osteogenic differentiation of BMSCs through the release of cytokines and signals.It is beneficial to bone defect repair and bone regeneration,and becomes a new therapeutic target for bone defect repair.Therefore,this article reviews the research status of the osteogenic effect of immune cells on BMSCs and related mechanisms.
关键词
骨髓间充质干细胞/免疫细胞/成骨分化/骨缺损修复和骨再生Key words
bone marrow mesenchymal stem cells/immune cell/osteogenic differentiation/bone defect repair and bone regeneration引用本文复制引用
基金项目
国家自然科学基金(81970903)
国家自然科学基金(82270959)
出版年
2024
国家科技期刊平台
NSTL
万方数据