LncRNA在牙周膜干细胞成骨分化中的作用
Functions of lncRNA in the osteogenic differentiation of periodontal ligament stem cells
曹帮萍 1苏俭生1
作者信息
- 1. 同济大学附属口腔医院口腔修复科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,同济大学口腔医学研究所,上海 200072
- 折叠
摘要
来源于牙相关组织的干细胞是口腔范围内特有的干细胞,对牙槽骨丢失后的再生或修复及牙槽骨的改建等具有重要意义.长链非编码RNA(long non-coding RNA,lncRNA)被发现参与牙相关组织干细胞的成骨向分化.本文就lncRNA在牙相关组织来源干细胞成骨分化过程中发挥的作用、调控的靶点及具体机制的最新研究进展进行综述.
Abstract
Stem cells derived from dental tissues are endemic in oral areas and they are of great significance to the regeneration of alveolar bone and the reconstruction of alveolar bone.Long non-coding RNA(lncRNA)was found to be involved in regulating osteogenic differentiation of stem cells derived from tooth-related tissues.In this review,we review the latest research progress on the role,regulatory targets and specific mechanisms of lncRNA in the osteogenic differentiation of tooth-related tissue-derived stem cells.
关键词
长链非编码RNA/牙周膜干细胞/成骨分化Key words
long non-coding RNA/periodontal ligament stem cells/osteogenesis differentiation引用本文复制引用
基金项目
国家自然科学基金(81873715)
国家自然科学基金(82170913)
上海市科委项目(201409006200)
出版年
2024
国家科技期刊平台
NSTL
万方数据