Serum levels of NGAL and YKL-40 in patients with oral squamous cell carcinoma and their diagnostic and prognostic value
Objective:To investigate the diagnostic and prognostic value of neutrophil gelatinase-associated lipocalin(NGAL)and chitinase protein 40(YKL-40)levels in patients with oral squamous cell carcinoma(OSCC).Methods:A total of 114 patients with OSCC admitted to our hospital from March 2017 to September 2020 were selected as the study objects(OSCC group),and 118 patients with benign tumor lesions in our hospital during the same period were selected as the control group.Serum levels of NGAL and YKL-40 were detected by enzym-linked immunosorbent assay(ELISA).The diagnostic value of serum NGAL and YKL-40 levels in OSCC was analyzed by receiver operating characteristic(ROC)curve.The prognosis of OSCC patients within 3 years after discharge was collected.Kaplan-Meier method was used to analyze the relationship between serum NGAL and YKL-40 levels and 3-year prognosis of OSCC patients.Cox proportional risk regression model was used to analyze the risk factors affecting the 3-year prognosis of OSCC patients.Results:Serum NGAL and YKL-40 levels in OSCC group were significantly higher than those in control group(P<0.001).The area under the curve(AUC)of serum NGAL,YKL-40 and combined OSCC were 0.716,0.744 and 0.791,respectively,and the AUC of combined diagnosis was better than that of single detection(P=0.008,0.047).There was no significant difference in the expression levels of serum NGAL and YKL-40 in OSCC patients with different age,gender,smoking history and disease site(P>0.05).The expression levels of serum NGAL and YKL-40 in patients with TNM stage Ⅲ to Ⅳ,tumor diameter≥3 cm and lymph node metastasis were significantly higher than those in patients with TNM stageⅠ to Ⅱ,tumor diameter<3 cm and no lymph node metastasis(P<0.001).The 3-year survival rate of patients with low expression of NGAL was higher than that of patients with high expression of NGAL,and the 3-year survival rate of patients with low expression of YKL-40 was higher than that of patients with high expression of YKL-40(P<0.05).NGAL and YKL-40 were risk factors for the prognosis of OSCC patients(P<0.001).Conclusion:Serum levels of NGAL and YKL-40 were elevated in OSCC patients,both of which had certain diagnostic value for OSCC and were related to the prognosis of patients.
oral squamous cell carcinomaneutrophil gelatinase-associated lipocalinchitinase protein 40diagnosisprognostic value
万方数据
维普
