摘要
糖尿病是慢性牙周炎(chronic periodontitis,CP)发生的危险因素,糖尿病患者长期高血糖会使机体产生大量高级糖基化终产物(advanced glycosylation end products,AGEs),通过氧化应激、细胞信号传导等途径将机体固有免疫系统激活,进而增强牙周组织的炎症反应,导致糖尿病相关性CP发生.破骨细胞(osteoclasts,OC)主要参与骨改建及骨吸收过程,对于维持人体骨组织稳态具有重要作用.OC与CP患者牙槽骨吸收密切相关,但与糖尿病相关CP的关系尚不明确.本文基于糖尿病相关CP发病机制,从炎症反应、AGEs、活性氧(reactive oxygen species,ROS)三个方面阐述OC与糖尿病相关CP的潜在关系,并做一综述.
Abstract
Diabetes is a risk factor for chronic periodontitis(CP).Long-term hyper-glycemia in diabetic patients leads to the production of advanced glycosylation end products(AGEs)activating the body's innate immune system through oxidative stress and cell signaling,which enhances the inflammatory response in the periodontal tissue and results in the development of diabetes-related CP.Osteoclasts(OC)play a vital role in the maintenance of bone homeostasis by participating in the process of bone resorption and remodeling.OC is closely related to alveolar bone resorption in CP patients.However,the relationship between OC and diabetes-related CP remains unclear.Based on the pathogenesis of diabetes-related CP,this paper expounds the potential relationship between OC and diabetes-related CP from three aspects:inflammatory response,AGEs,and reactive oxygen species(ROS),thus making a review.
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