Zn-based alloy is one of the most promising biodegradable medical materials with suitable degradation rate,good degradation behavior and good mechanical properties.It is poised for application in a variety of medical areas,including oral and maxillofacial surgery,dental implantation,periodontal bone defects,and orthopedic implants.Immune response is the key factor that determines the fate of implants after implantation,and macrophages are the most important factor affecting the immune response of implants.By inducing polarization of macrophages,the host inflammatory response to implants can be reduced and bone regeneration can be promoted.This paper reviews the current research status of biodegradable zinc alloys,including the effects of alloying,plastic deformation and surface modification on the mechanical properties,biodegradability and biocompatibility of zinc,providing a new idea for the use of biomaterials to regulate host immune response and promote bone regeneration.
维普
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