The treatment of oral diseases often needs to be assisted by oral materials,and the development of oral materials has also promoted the progress of oral medicine.The continuous emergence of new technologies and materials is driving the development of oral treatment technology,but there may also be potential hazards of materials to patients.Therefore,the biosafety of oral materials must be paid great attentions.In recent years,the application of rare earth materials in the field of modern biomedicine has been increasing,and has achieved good therapeutic effect on dental caries,periodontal diseases.This paper's aim is to provide reference for clinical application,research and development of related biological materials.