首页|Evolutionary conservation ofDmrt gene family in amphibi-ans, reptiles and birds

Evolutionary conservation ofDmrt gene family in amphibi-ans, reptiles and birds

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Sex determining gene Mab-3 of C. elegans and doublesex of Drosophila contain a common DNA binding motif called a DM domain, both of which regulate similar aspects of sexual development. Human doublesex-related gene DMRT1 has been identified, which also contains the conserved DM-related DNA-binding domain and plays an essential role in gonadal differentiation. We present the amplification of a broad spectrum of DM domain sequences from phylogenetic diverse vertebrates (Cynops orientalis, Chrysemys scripta elegans and Coturnix coturnix) using degenerate PCR. Our results further reveal the unexpected complexity and the evolutionary conservation of the DM domain gene family.

REN Lili、CHENG Hanhua、GUO Yiqing、HUANG Xiao、LIU Li、ZHOU Rongjia

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Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University

国家自然科学基金国家重点基础研究发展计划(973计划)

39770392G2000057004

2001

科学通报(英文版)
中国科学院

科学通报(英文版)

SCI
ISSN：1001-6538
年,卷(期)：2001.46(23)
  • 36
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