首页|Engineered stem cells by emerging biomedical stratagems

Engineered stem cells by emerging biomedical stratagems

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Stem cell therapy holds immense potential as a viable treatment for a widespread range of intractable disorders.As the safety of stem cell transplantation having been demonstrated in numerous clinical trials,various kinds of stem cells are currently utilized in medical applications.Despite the achievements,the therapeutic benefits of stem cells for diseases are limited,and the data of clinical researches are unstable.To optimize tthe effectiveness of stem cells,engineering approaches have been developed to enhance their inherent abilities and impart them with new functionalities,paving the way for the next generation of stem cell therapies.This review offers a detailed analysis of engineered stem cells,including their clin-ical applications and potential for future development.We begin by briefly introducing the recent advances in the production of stem cells(induced pluripotent stem cells(iPSCs),embryonic stem cells(ESCs),mesenchymal stem cells(MSCs)and hematopoietic stem cells(HSCs)).Furthermore,we present the latest developments of engineered strategies in stem cells,including engineered methods in molec-ular biology and biomaterial fields,and their application in biomedical research.Finally,we summarize the current obstacles and suggest future prospects for engineered stem cells in clinical translations and biomedical applications.

Stem cellsGenetic modificationBiomaterialsMicrofluidicsOrgan-on-a-chipBioprinting

Jinglin Wang、Xiaoxuan Zhang、Hanxu Chen、Haozhen Ren、Min Zhou、Yuanjin Zhao

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Department of Vascular Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China

Division of Hepatobiliary Surgery and Transplantation Surgery,Department of General Surgery,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

Shenzhen Research Institute,Southeast University,Shenzhen 518038,China

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaJiangsu Provincial Science and Technology Speciál Fund for Outstanding Young ScholarsNanjing Health Science and Technology Development Project for Distinguished Young Scholarsfundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing Universityfundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing UniversityNanjing Medical Science and Technique Development FoundationGuangdong Basic and Applied Basic Research FoundationShenzhen Science and Technology ProgramShenzhen Science and Technology Program

2022YFA1105300T22250038210066482270646BK20230051JQX220032021-LCYJ-PY-462022-LCYJ-PY-35ZKX210192021B1515120054JCYJ20210324133214038JCYJ20190813152616459

2024

10.1016/j.scib.2023.12.006

科学通报(英文版)
中国科学院

科学通报(英文版)

CSTPCD
ISSN：1001-6538
年,卷(期)：2024.69(2)
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