Engineered stem cells by emerging biomedical stratagems

Jinglin Wang ¹Xiaoxuan Zhang ²Hanxu Chen ²Haozhen Ren ²Min Zhou ³Yuanjin Zhao⁴

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作者信息

1. Department of Vascular Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China;Division of Hepatobiliary Surgery and Transplantation Surgery,Department of General Surgery,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China
2. Division of Hepatobiliary Surgery and Transplantation Surgery,Department of General Surgery,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China
3. Department of Vascular Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China
4. Department of Vascular Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China;Division of Hepatobiliary Surgery and Transplantation Surgery,Department of General Surgery,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China;Shenzhen Research Institute,Southeast University,Shenzhen 518038,China
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Abstract

Stem cell therapy holds immense potential as a viable treatment for a widespread range of intractable disorders.As the safety of stem cell transplantation having been demonstrated in numerous clinical trials,various kinds of stem cells are currently utilized in medical applications.Despite the achievements,the therapeutic benefits of stem cells for diseases are limited,and the data of clinical researches are unstable.To optimize tthe effectiveness of stem cells,engineering approaches have been developed to enhance their inherent abilities and impart them with new functionalities,paving the way for the next generation of stem cell therapies.This review offers a detailed analysis of engineered stem cells,including their clin-ical applications and potential for future development.We begin by briefly introducing the recent advances in the production of stem cells(induced pluripotent stem cells(iPSCs),embryonic stem cells(ESCs),mesenchymal stem cells(MSCs)and hematopoietic stem cells(HSCs)).Furthermore,we present the latest developments of engineered strategies in stem cells,including engineered methods in molec-ular biology and biomaterial fields,and their application in biomedical research.Finally,we summarize the current obstacles and suggest future prospects for engineered stem cells in clinical translations and biomedical applications.

Key words

Stem cells/Genetic modification/Biomaterials/Microfluidics/Organ-on-a-chip/Bioprinting

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基金项目

National Key Research and Development Program of China(2022YFA1105300)

National Natural Science Foundation of China(T2225003)

National Natural Science Foundation of China(82100664)

National Natural Science Foundation of China(82270646)

Jiangsu Provincial Science and Technology Speciál Fund for Outstanding Young Scholars(BK20230051)

Nanjing Health Science and Technology Development Project for Distinguished Young Scholars(JQX22003)

fundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing University(2021-LCYJ-PY-46)

fundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing University(2022-LCYJ-PY-35)

Nanjing Medical Science and Technique Development Foundation(ZKX21019)

Guangdong Basic and Applied Basic Research Foundation(2021B1515120054)

Shenzhen Science and Technology Program(JCYJ20210324133214038)

Shenzhen Science and Technology Program(JCYJ20190813152616459)

出版年

2024

科学通报(英文版)

中国科学院

科学通报(英文版)

CSTPCD

ISSN：1001-6538

参考文献量264

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