首页|Associations of remnant cholesterol with cardiovascular and cancer mortality in a nationwide cohort
Associations of remnant cholesterol with cardiovascular and cancer mortality in a nationwide cohort
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
The health significance of triglyceride-rich lipoproteins,also known as remnant cholesterol,has been increasingly recognized.However,evidence of their associations with cause-specific mortality in the gen-eral population was previously insufficient.To explore these associations and their heterogeneities across subgroups,a prospective cohort study was conducted including 3,403,414 community-based participants from ChinaHEART,an ongoing government-funded public health program throughout China,from November 2014 through December 2022.The study assessed mortality risk of all-cause mortality,cardio-vascular disease(CVD)mortality(including mortality from ischemic heart diseases(IHD),ischemic stroke(IS),and hemorrhagic stroke(HS),separately),and cancer mortality(including lung cancer,stomach can-cer,and liver cancer,separately).During the 4-year follow-up,23,646 individuals died from CVD(includ-ing 8807 from IHD,3067 from IS,and 5190 from HS),and 20,318 from cancer(including 6208 from lung cancer,3013 from liver cancer,and 2174 from stomach cancer).Compared with individuals with remnant cholesterol＜17.9 mg/dL,multivariable-adjusted mortality hazard ratios(HRs)for individuals with rem-nant cholesterol≥27.7mg/dL were 1.03(1.00-1.05)for all-cause mortality,1.17(1.12-1.21)for CVD(1.19(1.12-1.27)for IHD mortality,and 1.22(1.09-1.36)for IS mortality),and 0.90(0.87-0.94)for all-cancer mortality(0.94(0.87-1.02)for lung cancer,0.59(0.53-0.66)for liver cancer,and 0.73(0.64-0.83)for stomach cancer).In summary,this study revealed a correlation between increased remnant cholesterol levels and an elevated risk of cardiovascular disease mortality,as well as a reduced risk of mortality for certain types of cancer.
National Clinical Research Center of Cardiovascular Diseases,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China
Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450000,China
Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China
Shenzhen Center for Cardiovascular Diseases,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen 501800,China
Central China Sub-Center of the National Center for Cardiovascular Diseases,Zhengzhou 450000,China
展开 >
Chinese Academy of Medical Sciences Innovation Fund for Medical ScienceNational High-Level Hospital Clinical Research FundingMinistry of Finance of China and National Health Commission of China,and the 111 Project from the Ministry of Education of C
NETL
NSTL
万方数据
