首页|Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout
Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout
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N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone(6PPDQ)has attracted significant atten-tion due to its highly acute lethality to sensitive salmonids.However,studies investigating the mecha-nisms underlying its acute toxicity have been lacking.In this work,we demonstrated the sensitivity of rainbow trout to 6PPDQ-induced mortality.Moribund trout exhibited significantly higher brain concen-trations of 6PPDQ compared to surviving trout.In an in vitro model using human brain microvascular endothelial cells,6PPDQ can penetrate the blood-brain barrier and enhance blood-brain barrier perme-ability without compromising cell viability.The time spent in the top of the tank increased with rising 6PPDQ concentrations,as indicated by locomotion behavior tests.Furthermore,6PPDQ influenced neuro-transmitter levels and mRNA expression of neurotransmission-related genes in the brain and exhibited strong binding affinity to target neurotransmission-related proteins using computational simulations.The integrated biomarker response value associated with neurotoxicity showed a positive linear correla-tion with trout mortality.These findings significantly contribute to filling the knowledge gap between neurological impairments and apical outcomes,including behavioral effects and mortality,induced by 6PPDQ.
Xiao-Liang Liao、Zhi-Feng Chen、Shi-Ping Ou、Qian-Yi Liu、Shan-Hong Lin、Jia-Ming Zhou、Yujie Wang、Zongwei Cai
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Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control,Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health,School of Environmental Science and Engineering,Guangdong University of Technology,Guangzhou 510006,China
State Key Laboratory of Environmental and Biological Analysis,Department of Chemistry,Hong Kong Baptist University,Hong Kong 999077,China
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