首页|Hit-and-run vaccine system that overcomes limited neoantigen epitopes for efficient broad antitumor response

Hit-and-run vaccine system that overcomes limited neoantigen epitopes for efficient broad antitumor response

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Neoantigen cancer vaccines have been envisioned as one of the most promising means for cancer thera-pies.However,identifying neoantigens for tumor types with low tumor mutation burdens continues to limit the effectiveness of neoantigen vaccines.Herein,we proposed a"hit-and-run"vaccine strategy which primes T cells to attack tumor cells decorated with exogenous"neo-antigens".This vaccine strat-egy utilizes a peptide nanovaccine to elicit antigen-specific T cell responses after tumor-specific decora-tion with a nanocarrier containing the same peptide antigens.We demonstrated that a poly(2-oxazoline)s(POx)conjugated with OVA257-264 peptide through a matrix metalloprotease 2(MMP-2)sensitive linker could efficiently and selectively decorate tumor cells with OVA peptides in vivo.Then,a POx-based nanovaccine containing OVA257-264 peptides to elicit OVA-specific T cell responses was designed.In com-bination with this hit-and-run vaccine system,an effective vaccine therapy was demonstrated across tumor types even without OVA antigen expression.This approach provides a promising and uniform vac-cine strategy against tumors with a low tumor mutation burden.

Cancer immunotherapyCancer vaccineNeoantigenNanocarrierPoly(2-oxazoline)s

Hongyu Chen、Zichao Huang、Jiaxuan Li、Si Dong、Yudi Xu、Sheng Ma、Jiayu Zhao、Liping Liu、Tianmeng Sun、Wantong Song、Xuesi Chen

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School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China

Key laboratory of Polymer Ecomaterials,Changchun Institue of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China

Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education,Institute of Immunology,The First Hospital,Jilin University,Changchun 130021,China

Jilin Biomedical Polymers Engineering Laboratory,Changchun 130022,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaMinistry of Science and Technology of ChinaBureau of International Cooperation Chinese Academy of SciencesJilin Province Science and Technology Development PlanJilin Province Science and Technology Development PlanJilin Province Science and Technology Development PlanJilin Provincial International Cooperation Key Laboratory of Biomedical PolymersYouth Innovation Promotion Association of Chinese Academy of Sciences

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2024

10.1016/j.scib.2024.01.039

科学通报(英文版)
中国科学院

科学通报(英文版)

CSTPCD
ISSN：1001-6538
年,卷(期)：2024.69(7)
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