Abstract
The metabolite transport inhibition of tumor cells holds promise to achieve anti-tumor efficacy.Herein,we presented an innovative strategy to hinder the delivery of metabolites through the in-situ besieging tumor cells with polyphenolic polymers that strongly adhere to the cytomembrane of tumor cells.Simultaneously,these polymers underwent self-crosslinking under the induction of tumor oxidative stress microenvironment to form an adhesive coating on the surface of the tumor cells.This polyphenol coating effectively obstructed glucose uptake,reducing metabolic products such as lactic acid,glu-tathione,and adenosine triphosphate,while also causing reactive oxygen species to accumulate in the tumor cells.The investigation of various tumor models,including 2D cells,3D multicellular tumor spher-oids,and xenograft tumors,demonstrated that the polyphenolic polymers effectively inhibited the growth of tumor cells by blocking key metabolite transport processes.Moreover,this highly adhesive coating could bind tumor cells to suppress their metastasis and invasion.This work identified polyphe-nolic polymers as a promising anticancer candidate with a mechanism by impeding the mass transport of tumor cells.
基金项目
National Natural Science Foundation of China(52273302)
National Natural Science Foundation of China(52073230)
Ningbo Natural Science Foundation(2021J050)
Shaanxi Provincial Science Fund for Distinguished Young Scholars(2023-JC-JQ-32)
Fundamental Research Funds for the Central Universities,China()
NETL
NSTL
万方数据