首页|Swimming short fibrous nasal drops achieving intraventricular administration

Swimming short fibrous nasal drops achieving intraventricular administration

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Adequate drug delivery across the blood-brain barrier(BBB)is a critical factor in treating central nervous system(CNS)disorders.Inspired by swimming fish and the microstructure of the nasal cavity,this study is the first to develop swimming short fibrous nasal drops that can directly target the nasal mucosa and swim in the nasal cavity,which can effectively deliver drugs to the brain.Briefly,swimming short fibrous nasal drops with charged controlled drug release were fabricated by electrospinning,homogenization,the π-π conjugation between indole group of fibers,the benzene ring of leucine-rich repeat kinase 2(LRRK2)inhibitor along with charge-dipole interaction between positively charged poly-lysine(PLL)and negatively charged surface of fibers;this enabled these fibers to stick to nasal mucosa,prolonged the residence time on mucosa,and prevented rapid mucociliary clearance.In vitro,swimming short fibrous nasal drops were biocompatible and inhibited microglial activation by releasing an LRRK2 inhibi-tor.In vivo,luciferase-labelled swimming short fibrous nasal drops delivered an LRRK2 inhibitor to the brain through the nasal mucosa,alleviating cognitive dysfunction caused by sepsis-associated encephalopathy by inhibiting microglial inflammation and improving synaptic plasticity.Thus,swim-ming short fibrous nasal drops is a promising strategy for the treatment of CNS diseases.

Nasal dropsElectrospun short fibersNasal mucosaIntraventricular administrationBrain diseases

Juan Wang、Qiuyun Wang、Yifei Fu、Min Lu、Liang Chen、Zhiheng Liu、Xiaohan Fu、Xiyu Du、Buwei Yu、Han Lu、Wenguo Cui

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Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Department of Anesthesiology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Department of Anesthesiology,Shenzhen Second People's Hospital,The First Affiliated Hospital of Shenzhen University,Shenzhen 518035,China

Department of Anesthesiology,Huadong Hospital Affiliated to Fudan University,Shanghai 200040,China

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国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金Shanghai Municipal Health CommissionSanming Project of Medicine in Shenzhen

2020YFA090820082271204817711383200093720204Y0354SZSM202211007

2024

10.1016/j.scib.2024.03.013

科学通报(英文版)
中国科学院

科学通报(英文版)

CSTPCD
ISSN：1001-6538
年,卷(期)：2024.69(9)
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