首页|Spatiotemporal patterns of the pregnancy microbiome and links to reproductive disorders

Spatiotemporal patterns of the pregnancy microbiome and links to reproductive disorders

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The microbiome of females undergoes extensive remodeling during pregnancy,which is likely to have an impact on the health of both mothers and offspring.Nevertheless,large-scale integrated investigations characterizing microbiome dynamics across key body habitats are lacking.Here,we performed an exten-sive meta-analysis that compiles and analyzes microbiome profiles from＞10,000 samples across the gut,vagina,and oral cavity of pregnant women from diverse geographical regions.We have unveiled unex-pected variations in the taxonomic,functional,and ecological characteristics of microbial communities throughout the course of pregnancy.The gut microbiota showed distinct trajectories between Western and non-Western populations.The vagina microbiota exhibited fluctuating transitions at the genus level across gestation,while the oral microbiota remained relatively stable.We also identified distinctive microbial signatures associated with prevalent pregnancy-related disorders,including opposite varia-tions in the oral and gut microbiota of patients with gestational diabetes and disrupted microbial net-works in preterm birth.This study establishes a comprehensive atlas of the pregnancy microbiome by integrating multidimensional datasets and offers foundational insights into the intricate interplay between microbes and host factors that underlie reproductive health.

Pregnancy microbiomeData integrationSpatiotemporal patternsMicrobial biomarkers

Liwen Xiao、Tian Zhou、Zhenqiang Zuo、Ningxia Sun、Fangqing Zhao

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Beijing Institutes of Life Science,Chinese Academy of Sciences,Beijing 100101,China

Key Laboratory of Systems Biology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China

University of Chinese Academy of Sciences,Beijing 100049,China

Department of Reproductive Medicine,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China

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国家重点研发计划国家重点研发计划国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金Military Innovation Project Special ProjectShanghai Shen-Kang Hospital Development Center Special Medical Enterprise Integration Innovation AchievementsPostdoctoral Fellowship Program of CPSF

2022YFA13039002021YFA13010002022YFC 270470232001082320250098227166221JSZ06SHDC2022CRD007GZC20232650

2024

10.1016/j.scib.2024.02.001

科学通报(英文版)
中国科学院

科学通报(英文版)

CSTPCD
ISSN：1001-6538
年,卷(期)：2024.69(9)
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