Abstract
The microbiome of females undergoes extensive remodeling during pregnancy,which is likely to have an impact on the health of both mothers and offspring.Nevertheless,large-scale integrated investigations characterizing microbiome dynamics across key body habitats are lacking.Here,we performed an exten-sive meta-analysis that compiles and analyzes microbiome profiles from＞10,000 samples across the gut,vagina,and oral cavity of pregnant women from diverse geographical regions.We have unveiled unex-pected variations in the taxonomic,functional,and ecological characteristics of microbial communities throughout the course of pregnancy.The gut microbiota showed distinct trajectories between Western and non-Western populations.The vagina microbiota exhibited fluctuating transitions at the genus level across gestation,while the oral microbiota remained relatively stable.We also identified distinctive microbial signatures associated with prevalent pregnancy-related disorders,including opposite varia-tions in the oral and gut microbiota of patients with gestational diabetes and disrupted microbial net-works in preterm birth.This study establishes a comprehensive atlas of the pregnancy microbiome by integrating multidimensional datasets and offers foundational insights into the intricate interplay between microbes and host factors that underlie reproductive health.
基金项目
国家重点研发计划(2022YFA1303900)
国家重点研发计划(2021YFA1301000)
国家重点研发计划(2022YFC 2704702)
国家自然科学基金(32001082)
国家自然科学基金(32025009)
国家自然科学基金(82271662)
Military Innovation Project Special Project(21JSZ06)
Shanghai Shen-Kang Hospital Development Center Special Medical Enterprise Integration Innovation Achievements(SHDC2022CRD007)
Postdoctoral Fellowship Program of CPSF(GZC20232650)
NETL
NSTL
万方数据