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Development of new techniques and clinical applications of liquid biopsy in lung cancer management

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Lung cancer is an exceedingly malignant tumor reported as having the highest morbidity and mortality of any cancer worldwide,thus posing a great threat to global health.Despite the growing demand for pre-cision medicine,current methods for early clinical detection,treatment and prognosis monitoring in lung cancer are hampered by certain bottlenecks.Studies have found that during the formation and develop-ment of a tumor,molecular substances carrying tumor-related genetic information can be released into body fluids.Liquid biopsy(LB),a method for detecting these tumor-related markers in body fluids,maybe a way to make progress in these bottlenecks.In recent years,LB technology has undergone rapid advancements.Therefore,this review will provide information on technical updates to LB and its poten-tial clinical applications,evaluate its effectiveness for specific applications,discuss the existing limita-tions of LB,and present a look forward to possible future clinical applications.Specifically,this paper will introduce technical updates from the prospectives of engineering breakthroughs in the detection of membrane-based LB biomarkers and other improvements in sequencing technology.Additionally,it will summarize the latest applications of liquid biopsy for the early detection,diagnosis,treatment,and prognosis of lung cancer.We will present the interconnectedness of clinical and laboratory issues and the interplay of technology and application in LB today.

Liquid biopsy techniquesLung cancerCirculating tumor cellsCirculating tumor DNASequencing technologyClinical application

Kezhong Chen、Yue He、Wenxiang Wang、Xiaoqiu Yuan、David P.Carbone、Fan Yang

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Department of Thoracic Surgery,Peking University People's Hospital,Beijing 100044,China

Peking University People's Hospital Thoracic Oncology Institute & Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer,Beijing 100044,China

Peking University Health Science Center,Beijing 100191,China

Thoracic Oncology Center,Ohio State University,Columbus 43026,USA

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Science,Technology & Innovation Project of Xiongan New AreaChinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical SciencesClinical Medicine Plus X-Young Scholars Project,Peking UniversityFundamental Research Funds for the Centra l UniversitiesResearch Unit of Intelligence Diagnosis and Treatment in Early Nonsmall Cell Lung Cancer,Chinese Academy of Medical Sciences国家自然科学基金国家自然科学基金国家自然科学基金北京大学项目

2023XAGG00712022-I2M-C&T-B-120PKU2023LCXQ0082021RU002920592038207256692259303RZ2022-03

2024

10.1016/j.scib.2024.03.062

科学通报(英文版)
中国科学院

科学通报(英文版)

CSTPCD
ISSN：1001-6538
年,卷(期)：2024.69(10)
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