首页|Synergistic use of photocatalysis and convergent paired electrolysis for nickel-catalyzed arylation of cyclic alcohols

Synergistic use of photocatalysis and convergent paired electrolysis for nickel-catalyzed arylation of cyclic alcohols

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The merging of transition metal catalysis with electrochemistry has become a powerful tool for organic synthesis because catalysts can govern the reactivity and selectivity.However,coupling catalysts with alkyl radical species generated by anodic oxidation remains challenging because of electrode passivation,dimerization,and overoxidation.In this study,we developed convergent paired electrolysis for the cou-pling of nickel catalysts with alkyl radicals derived from photoinduced ligand-to-metal charge-transfer of cyclic alcohols and iron catalysts,providing a practical method for site-specific and remote arylation of ketones.The synergistic use of photocatalysis with convergent paired electrolysis can provide alternative avenues for metal-catalyzed radical coupling reactions.

Organic electrochemistryElectrophotocatalysisPaired electrolysisNi catalysisRemote arylation

Zhao-Ran Liu、Xiao-Yu Zhu、Jian-Feng Guo、Cong Ma、Zhiwei Zuo、Tian-Sheng Mei

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State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200032,China

National Key R&D Program of ChinaStrategic Priority Research Program of the Chinese Academy of SciencesNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaS&TCSM of ShanghaiNatural Science Foundation of Ningbo

2021YFA1500100XDB061000021821002223611428342210129421ZR14765002023J035

2024

10.1016/j.scib.2024.04.031

科学通报(英文版)
中国科学院

科学通报(英文版)

CSTPCD
ISSN：1001-6538
年,卷(期)：2024.69(12)
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