Synergistic use of photocatalysis and convergent paired electrolysis for nickel-catalyzed arylation of cyclic alcohols

Zhao-Ran Liu ¹Xiao-Yu Zhu ¹Jian-Feng Guo ¹Cong Ma ¹Zhiwei Zuo ¹Tian-Sheng Mei¹

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作者信息

1. State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200032,China
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Abstract

The merging of transition metal catalysis with electrochemistry has become a powerful tool for organic synthesis because catalysts can govern the reactivity and selectivity.However,coupling catalysts with alkyl radical species generated by anodic oxidation remains challenging because of electrode passivation,dimerization,and overoxidation.In this study,we developed convergent paired electrolysis for the cou-pling of nickel catalysts with alkyl radicals derived from photoinduced ligand-to-metal charge-transfer of cyclic alcohols and iron catalysts,providing a practical method for site-specific and remote arylation of ketones.The synergistic use of photocatalysis with convergent paired electrolysis can provide alternative avenues for metal-catalyzed radical coupling reactions.

Key words

Organic electrochemistry/Electrophotocatalysis/Paired electrolysis/Ni catalysis/Remote arylation

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基金项目

National Key R&D Program of China(2021YFA1500100)

Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0610000)

National Natural Science Foundation of China(21821002)

National Natural Science Foundation of China(22361142834)

National Natural Science Foundation of China(22101294)

S&TCSM of Shanghai(21ZR1476500)

Natural Science Foundation of Ningbo(2023J035)

出版年

2024

科学通报(英文版)

中国科学院

科学通报(英文版)

CSTPCD

ISSN：1001-6538

参考文献量2

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