Piezocatalytically-induced controllable mineralization scaffold with bone-like microenvironment to achieve endogenous bone regeneration

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外文摘要：Orderly hierarchical structure with balanced mechanical,chemical,and electrical properties is the basis of the natural bone microenvironment.Inspired by nature,we developed a piezocatalytically-induced controlled mineralization strategy using piezoelectric polymer poly-L-lactic acid(PLLA)fibers with ordered micro-nano structures to prepare biomimetic tissue engineering scaffolds with a bone-like microenvironment(pcm-PLLA),in which PLLA-mediated piezoelectric catalysis promoted the in-situ polymerization of dopamine and subsequently regulated the controllable growth of hydroxyapatite crys-tals on the fiber surface.PLLA fibers,as analogs of mineralized collagen fibers,were arranged in an ori-ented manner,and ultimately formed a bone-like interconnected pore structure;in addition,they also provided bone-like piezoelectric properties.The uniformly sized HA nanocrystals formed by controlled mineralization provided a bone-like mechanical strength and chemical environment.The pcm-PLLA scaf-fold could rapidly recruit endogenous stem cells,and promote their osteogenic differentiation by activat-ing cell membrane calcium channels and PI3K signaling pathways through ultrasound-responsive piezoelectric signals.In addition,the scaffold also provided a suitable microenvironment to promote macrophage M2 polarization and angiogenesis,thereby enhancing bone regeneration in skull defects of rats.The proposed piezocatalytically-induced controllable mineralization strategy provides a new idea for the development of tissue engineering scaffolds that can be implemented for multimodal physical stimulation therapy.

外文关键词：

Piezoelectric catalysisControllable mineralizationBiomimeticBone repairBiodegradable

作者：

Xi Cui、Lingling Xu、Yizhu Shan、Jiaxuan Li、Jianying Ji、Engui Wang、Baokun Zhang、Xiaozhou Wen、Yuan Bai、Dan Luo、Chunying Chen、Zhou Li

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作者单位：

Beijing Key Laboratory of Micro-nano Energy and Sensor,Beijing Institute of Nanoenergy and Nanosystems,Chinese Academy of Sciences,Beijing 101400,China

School of Nanoscience and Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

New Cornerstone Science Laboratory,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing 100190,China

基金：

Beijing Natural Science FoundationNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNew Cornerstone Science FoundationMajor Instrument Project of the National Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of China

项目编号：

L212010T212500352372174220278102022YFB38047032022YFE01117002021YFA12009002021YFB32012042022YFB3205602

出版年：

2024

DOI：

10.1016/j.scib.2024.04.002

科学通报(英文版)

中国科学院

科学通报(英文版)

CSTPCD

ISSN：1001-6538

年,卷(期)：2024.69(12)