Exploring the link between brain topological resilience and cognitive performance in the context of aging and vascular risk factors:A cross-ethnicity population-based study

Hao Liu ¹Jing Jing ²Jiyang Jiang ³Wei Wen ³Wanlin Zhu ²Zixiao Li ²Yuesong Pan ²Xueli Cai ⁴Chang Liu ¹Yijun Zhou ¹Xia Meng ²Yilong Wang ²Hao Li ⁵Yong Jiang ²Huaguang Zheng ²Suying Wang ⁶Haijun Niu ¹Nicole Kochan ³Henry Brodaty ³Tiemin Wei ⁷Perminder S.Sachdev ³Yubo Fan ¹Tao Liu ¹Yongjun Wang²

扫码查看

作者信息

1. Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China
2. China National Clinical Research Center for Neurological Diseases,Beijing 100070,China;Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China
3. Neuropsychiatric Institute,Prince of Wales Hospital,Sydney NSW 2031,Australia;Centre for Healthy Brain Ageing(CHeBA),Discipline of Psychiatry and Mental Health,School of Clinical Medicine,UNSW Medicine,Sydney NSW 2052,Australia
4. Department of Neurology,Lishui Hospital,Zhejiang University School of Medicine,Lishui 323000,China
5. China National Clinical Research Center for Neurological Diseases,Beijing 100070,China
6. Cerebrovascular Research Lab,Lishui Hospital,Zhejiang University School of Medicine,Lishui 323000,China
7. Department of Cardiology,Lishui Hospital,Zhejiang University School of Medicine,Lishui 323000,China
折叠

Abstract

Brain aging is typically associated with a significant decline in cognitive performance.Vascular risk fac-tors(VRF)and subsequent atherosclerosis(AS)play a major role in this process.Brain resilience reflects the brain's ability to withstand external perturbations,but the relationship of brain resilience with cog-nition during the aging process remains unclear.Here,we investigated how brain topological resilience(BTR)is associated with cognitive performance in the face of aging and vascular risk factors.We used data from two cross-ethnicity community cohorts,PolyvasculaR Evaluation for Cognitive Impairment and Vascular Events(PRECISE,n=2220)and Sydney Memory and Ageing Study(MAS,n=246).We conducted an attack simulation on brain structural networks based on k-shell decomposition and node degree cen-trality.BTR was defined based on changes in the size of the largest subgroup of the network during the simulation process.Subsequently,we explored the negative correlations of BTR with age,VRF,and AS,and its positive correlation with cognitive performance.Furthermore,using structural equation modeling(SEM),we constructed path models to analyze the directional dependencies among these variables,demonstrating that aging,AS,and VRF affect cognition by disrupting BTR.Our results also indicated the specificity of this metric,independent of brain volume.Overall,these findings underscore the sup-portive role of BTR on cognition during aging and highlight its potential application as an imaging marker for objective assessment of brain cognitive performance.

Key words

Brain resilience/Vascular risk factors/Cognition decline/K-shell decomposition/Network attack simulation

引用本文复制引用

基金项目

National Natural Science Foundation of China(82372040)

National Natural Science Foundation of China(82271329)

National Key Research and Development Program of China(2022YFC2504900)

National Key Research and Development Program of China(2016YFC0901002)

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-12M-5-029)

Key Science & Technologies R&D Program of Lishui City(2019ZDYF18)

AstraZeneca Investment(China)()

Beijing Natural Science Foundation(Z200016)

three National Health & Medical Research Council(NHMRC)Program Grants(ID350833)

three National Health & Medical Research Council(NHMRC)Program Grants(ID568969)

three National Health & Medical Research Council(NHMRC)Program Grants(APP1093083)

PRECISE and MAS research teams()

出版年

2024

科学通报(英文版)

中国科学院

科学通报(英文版)

CSTPCD

ISSN：1001-6538

段落导航