A citrullinated antigenic vaccine in treatment of autoimmune arthritis

Xu Jin ¹Tianya Dong ²Qian Wang ³Yang Xie ⁴Xiangyu Fang ⁴Chaonan Wei ⁴Shuyan Liu ⁴Xi Zheng ¹Ping Wang ⁴Danxue Zhu ¹Lulu Cao ⁴Suwei Dong ³Kechi Fang ²Chao Zhong ⁵Jing Wang ²Fanlei Hu ⁶Zhanguo Li⁷

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作者信息

1. Department of Rheumatology and Immunology,Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis,Beijing 100044,China;Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China
2. CAS Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,Chi-na;Department of Psychology,University of Chinese Academy of Sciences,Beijing 100049,China
3. Department of Chemical Biology,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China
4. Department of Rheumatology and Immunology,Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis,Beijing 100044,China
5. Institute of Systems Biomedicine,Department of Immunology,NHC Key Laboratory of Medical Immunology(Peking University),Beijing Key Laboratory of Tumor Systems Biology,Peking University Health Science Center,Beijing 100191,China
6. Department of Rheumatology and Immunology,Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis,Beijing 100044,China;State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;Department of Integration of Chinese and Western Medicine,School of Basic Medical Sciences,Peking University,Beijing 100191,China
7. Department of Rheumatology and Immunology,Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis,Beijing 100044,China;Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China;Department of Integration of Chinese and Western Medicine,School of Basic Medical Sciences,Peking University,Beijing 100191,China
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Abstract

Rheumatoid arthritis(RA)is an inflammatory autoimmune disease triggered by antigenic peptides with environmental and genetic risk factors.It has been shown that antigen-specific targeting could be a promising therapeutical strategy for RA by restoring immune tolerance to self-antigens without compro-mising normal immunity.Citrullination of antigens enhances antigenic properties and induces autoim-mune responses.Here,we showed that citrullinated antigenic(citAg)vaccine ameliorated collagen-induced arthritis with decreased T-helper 1(Th1)and Th17 cells,downregulated proinflammatory cytokines including interlukin-6 and tumor necrosis factor-α,and inhibited antigen recall responses.B cell receptor sequencing further revealed that citAg vaccine could dampen the dysregulated V(D)J recom-bination,restoring the immune repertoire.Taken together,the results demonstrated that citAg vaccine might have a therapeutic effect on RA.

Key words

CitAg/Citrullination/Collagen type Ⅱ/Therapeutic vaccine/Immune tolerance/Rheumatoid arthritis

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基金项目

Guangdong Basic and Applied Basic Research Foundation(2020B1515130005)

National Natural Science Foundation of China(82371807)

National Natural Science Foundation of China(82171773)

National Natural Science Foundation of China(92374202)

National Natural Science Foundation of China(32141004)

National Key R&D Program of China(2022YFC3602000)

Beijing Nova Program(Z181100006218044)

Beijing Nova Program(Z211100002121163)

出版年

2024

科学通报(英文版)

中国科学院

科学通报(英文版)

CSTPCD

ISSN：1001-6538

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