首页|The mechanisms,hallmarks,and therapies for brain aging and age-related dementia

The mechanisms,hallmarks,and therapies for brain aging and age-related dementia

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Age-related cognitive decline and dementia are significant manifestations of brain aging.As the elderly population grows rapidly,the health and socio-economic impacts of cognitive dysfunction have become increasingly significant.Although clinical treatment of dementia has faced considerable challenges over the past few decades,with limited breakthroughs in slowing its progression,there has been substantial progress in understanding the molecular mechanisms and hallmarks of age-related dementia(ARD).This progress brings new hope for the intervention and treatment of this disease.In this review,we categorize the latest findings in ARD biomarkers into four stages based on disease progression:Healthy brain,pre-clinical,mild cognitive impairment,and dementia.We then systematically summarize the most promis-ing therapeutic approaches to prevent or slow ARD at four levels:Genome and epigenome,organelle,cell,and organ and organism.We emphasize the importance of early prevention and detection,along with the implementation of combined treatments as multimodal intervention strategies,to address brain aging and ARD in the future.

Brain agingAge-related dementiaCognitive dysfunctionAlzheimer's disease

Shiyun Jin、Wenping Lu、Juan Zhang、Li Zhang、Fangbiao Tao、Ye Zhang、Xianwen Hu、Qiang Liu

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Department of Neurology,The First Affiliated Hospital of USTC,Center for Advanced Interdisciplinary Science and Biomedicine of IHM,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China

Anhui Province Key Laboratory of Biomedical Aging Research,University of Science and Technology of China,Hefei 230027,China

Department of Anesthesiology,the Second Affiliated Hospital of Anhui Medical University,Hefei 230601,China

Key Laboratory of Anesthesiology and Periopera

Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes,Anhui Medical University,Hefei 230601,China

Institute on Aging and Brain Disorders,The First Affiliated Hospital of USTC,University of Science and Technology of China,Hefei 230027,China

Laboratory for Integrative Neuroscience,National Institute on Alcohol Abuse and Alcoholism,National Institutes of Health,Bethesda,MD 20892,USA

MOE Key Laboratory of Population Health Across Life Cycle,Anhui Medical University,Hefei 230032,China

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2024

科学通报(英文版)
中国科学院

科学通报(英文版)

CSTPCD
ISSN:1001-6538
年,卷(期):2024.69(23)