首页|Now and future:Strategies for diagnosis,prevention and therapies for Alzheimer's disease

Now and future:Strategies for diagnosis,prevention and therapies for Alzheimer's disease

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After a number of failed drug studies on Alzheimer's disease(AD)over the past decade,clinical trials of AD started to show encouraging results and were approved or pending approval for clinical use.However,controversies on the clinically meaningful benefits and risks of brain edema and microhemorrhages have reminded us to think further about monitoring treatment and developing new drug targets.The goal of this review is to find insights from clinical trials that aimed at two key pathological features of AD,i.e.,amyloid-p(Ap)and tau protein,and to explore other targets such as anti-inflammation in AD.The com-plex pathophysiology of AD may require combination therapies rather than monotherapy.Throughout the course of AD,multiple pathways are disrupted,presenting a multitude of possible therapeutic targets for designing prevention and intervention for AD.

Alzheimer's diseaseDementiaAmyloidTauBiomarkerTreatment

Jiong Shi、Jacques Touchon、Lefkos T Middleton、Mercé Boada Rovira、Robert Vassar、Bruno Vellas、Yong Shen

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Department of Neurology,Institute on Aging and Brain Disorders,the First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China

Neurodegenerative Disorder Research Center,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230026,China

Institute of Neuroscience,University Hospital Gui de Chauliac-Montpellier,Montpellier 34295,France

Ageing Epidemiology(AGE)Research,School of Public Health,Imperial College,London SW7 2AZ,UK

Centro de Investigación Biomédica en Red sobre,Enfermedades Neurodegenerativas(CIBERNED),Universitat International de Catalunya-Barcelona,Barcelona 08028,Spain

Department of Cell Biology,Medical School,Department of Neurology,Feinberg School of Medicine,Northwestern University,Chicago,IL 60611,USA

IHU HealthAge,WHO Collaborating Center for Frailty,Clinical & Geoscience Research and Geriatric Training,Toulouse University Hospital,INSERM UMR 1295,University Paul Sabatier,Toulouse 31000,France

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2024

10.1016/j.scib.2024.09.042

科学通报(英文版)
中国科学院

科学通报(英文版)

CSTPCD
ISSN：1001-6538
年,卷(期)：2024.69(23)