Bone aging and extracellular vesicles

扫码查看

原文链接

NETL
NSTL
万方数据

外文标题：Bone aging and extracellular vesicles

外文摘要：Bone aging,a major global health concern,is the natural decline in bone mass and strength.Concurrently,extracellular vesicles(EVs),tiny membrane-bound particles produced by cells,have gained recognition for their roles in various physiological processes and age-related diseases.The interaction between EVs and bone aging is of growing interest,particularly their effects on bone metabolism,which become increasingly critical with advancing age.In this review,we explored the biology,types,and functions of EVs and emphasized their regulatory roles in bone aging.We examined the effects of EVs on bone metabolism and highlighted their potential as biomarkers for monitoring bone aging progression.Furthermore,we discussed the therapeutic applications of EVs,including targeted drug delivery and bone regeneration,and addressed the challenges associated with EV-based therapies,including the technical complexities and regulatory issues.We summarized the current research and clinical trials investigating the role of EVs in bone aging and suggested future research directions.These include the potential for personalized medicine using EVs and the integration of EV research with advanced technologies to enhance the management of age-related bone health.This analysis emphasized the transformative potential of EVs in understanding and managing bone aging,thereby marking a significant advancement in skeletal health research.

外文关键词：

Extracellular vesiclesBone agingBone metabolismBiomarkerBone regeneration

作者：

Jian Wang、Yuanwei Zhang、Sicheng Wang、Xinglong Wang、Yingying Jing、Jiacan Su

展开 >

作者单位：

Department of Orthopedics,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

Trauma Orthopedics Center,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

Institute of Musculoskeletal Injury and Translational Medicine of Organoids,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

Institute of Translational Medicine,Shanghai University,Shanghai 200444,China

Sch

Nat

National Center for Translational Medicine SHU Branch,Shanghai University,Shanghai 200444,China

Department of Orthopedics,Shanghai Zhongye Hospital,Shanghai 200941,China

Department of Pharmacology and Toxicology,University of Arizona,Tucson,AZ 85721,USA

展开 >

关键词：

Extracellular vesicles Bone aging Bone metabolism Biomarker Bone regeneration

出版年：

2024

DOI：