Objective To analyze the clinical effect of the combined treatment of Qingre Decoction for the acute stage of chronic bronchitis. Methods 80 patients with acute chronic bronchitis admitted to our hospital from June 2020 to June 2022 were divided into two groups according to the random number table method. 40 patients in the control group received conventional treatment, and 40 patients in the study group received decoction for Qi, Yin and heat clearing on the basis of the control group. Results The duration of wheezing relief, sputum relief, cough relief and pulmonary rales relief in the study group were lower than those in the control group, and the difference was statistically significant (P<0.05). The incidence and duration of acute chronic bronchitis in the study group were lower than those in the control group, and the difference was statistically significant (P<0.05). The total effective rate of the study group was 92.50% higher than that of the control group (72.50%), and the difference was statistically significant (P<0.05). Conclusion In the treatment of patients with acute chronic bronchitis, the combination of Yiqi, YangYin and Qingre decoction can reduce the frequency and duration of attacks in acute chronic bronchitis, relieve patients'' clinical symptoms, and improve the total effective rate.