Objective To analyze the accuracy of enhanced CT and MRI in liver cancer screening. Methods The study lasted from January 2020 to July 2021, and the subjects were liver cancer screening patients. Eighty patients admitted to our hospital were included as research samples. All patients were given enhanced CT examination and MRI examination, and pathological examination results were used as the gold standard to analyze the detection results. Results Among the 80 patients, 56 cases were confirmed by postoperative pathological examination, 44 cases were confirmed by enhanced CT examination, the detection rate was 78.57% (44/56). There were 54 cases confirmed by MRI examination, the detection rate was 96.43% (54/56), the detection rate of MRI was significantly higher than that of enhanced CT, the difference was statistically significant (P<0.05). There was no significant difference in the diagnostic accuracy of different types of liver cancer between enhanced CT and MRI (P>0.05). Conclusion Enhanced CT and MRI have certain application value in liver cancer screening, but the detection rate of MRI is higher, and the corresponding diagnostic methods can be reasonably selected according to the actual situation of patients.