首页|HP菌株感染及胃蛋白酶原在上消化道疾病中的变化以及对胃癌的诊断价值

HP菌株感染及胃蛋白酶原在上消化道疾病中的变化以及对胃癌的诊断价值

HP strain infection and changes of pepsinogen in upper digestive tract diseases and its diagnostic value for gastric cancer

扫码查看
原文链接
  • 万方数据
目的 本研究以胃癌、消化性溃疡、慢性萎缩性胃炎、慢性萎缩性胃炎、慢性非萎缩性胃炎等为代表,探讨幽门螺旋杆菌株(CagA与VacA)和胃蛋白酶原(PGI与PGII)在其中的变化,探索其在胃癌鉴别诊断中的作用.方法 以贵州医科大学附属肿瘤医院2014年12月～2015年12月收治的102例上消化道疾病病患为样本,其中22例为胃癌患者,38例为消化道溃疡患者(20例胃溃疡,18例十二指肠溃疡),21例为慢性萎缩性胃炎患者,21例为慢性非萎缩性胃炎患者.所有疾病都经过了内窥镜和病理诊断确诊,测定血浆中CagA和VacA的阳性反应和阳性率,以及PGI和PGII水平,并通过计算得出PGR值(PGI/PGII),观察胃炎、消化性溃疡、慢性萎缩性胃炎、慢性非萎缩性胃炎中的HPI阳性率以及PGI、PGII、PGR的变化.结果 102例病人接受内窥镜和病理诊断结果显示:慢性非萎缩性胃炎、慢性萎缩性胃炎、胃溃疡、十二指肠溃疡、胃癌HP感染发生率分别是38.10％、61.90％、75.00％、66.67％、86.36％,4个组间HP的阳性检出量都高于对照组,P ＜ 0.05,差异有统计学意义;胃癌组幽门螺旋杆菌阳性率较其他组高,P ＜ 0.05,差异有统计学意义.结论 HPI具有较高的致病力,而且各上消化道的幽门螺旋杆菌的菌株间有明显的差别;PGI和PGR与HPI感染的比例存在显著的负相关关系,因此,幽门螺杆菌株结合胃蛋白酶原检测对早期胃癌的筛选具有重要的作用.
Objective To investigate the changes of Helicobacter pylori (CagA and VacA) and pepsinogen (PGI and PGII) in gastric cancer, peptic ulcer, chronic atrophic gastritis, chronic atrophic gastritis and chronic non-atrophic gastritis, and explore their role in the differential diagnosis of gastric cancer. Methods A total of 102 patients with upper digestive tract diseases admitted to the Affiliated Cancer Hospital of Guizhou Medical University from December 2014 to December 2015 were selected as samples, including 22 patients with gastric cancer, 38 patients with digestive tract ulcers (20 patients with gastric ulcer, 18 patients with duodenal ulcer), and 21 patients with chronic atrophic gastritis. Twenty-one patients with chronic non-atrophic gastritis. All the diseases were confirmed by endoscopic and pathological diagnosis. The positive reaction and positive rate of CagA and VacA in plasma, as well as the levels of PGI and PGII were determined, and the PGR value (PGI/PGII) was calculated. To observe the positive rate of HPI and the changes of PGI, PGII and PGR in gastritis, peptic ulcer, chronic atrophic gastritis and chronic non-atrophic gastritis. Results 102 patients received endoscopic and pathological diagnosis results showed that: The incidence rates of HP infection in chronic non-atrophic gastritis, chronic atrophic gastritis, gastric ulcer, duodenal ulcer and gastric cancer were 38.10％, 61.90％, 75.00％, 66.67％ and 86.36％, respectively. The positive amount of HP detected in the 4 groups was higher than that in the control group, P＜0.05, and the difference was statistically significant. The positive rate of H. pylori in gastric cancer group was higher than that in other groups (P＜0.05), and the difference was statistically significant. Conclusion HPI has high pathogenicity, and there are obvious differences among the strains of H. pylori in the upper digestive tract. There is a significant negative correlation between PGI and PGR and the proportion of HPI infection. Therefore, the detection of Helicobacter pylori strains combined with pepsinogen plays an important role in the screening of early gastric cancer.

helicobacter pyloriHp strain infectionupper digestive tract diseasesdiagnosis of gastric cancer

李梅、王燕、Zhou Li

展开 >

贵航贵阳医院,贵州 贵阳 550002

贵州医科大学附属肿瘤医院,贵州 贵阳 550002

Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

幽门螺旋杆菌 Hp菌株感染 上消化道疾病 胃癌诊断

2023

10.3969/j.issn.1672-9714.2023.01.082

科学养生
中国医院管理杂志社

科学养生

影响因子：0.019
ISSN：1672-9714
年,卷(期)：2023.26(1)
  • 7