In recent years, clinical medicine has been developing continuously. In many major surgeries, anesthesia needs general anesthesia, so as to make the operation safe and progress smoothly. However, anesthesia through general anesthesia surgery is easy to cause intraoperative hypotension, and reduced blood pressure will lead to various risk events, which will affect the overall safety of the patient. Therefore, we have to choose scientific and reasonable methods for intervention in clinical surgery. The application of drugs to prevent hypotension in surgery is a common means. This paper mainly analyzes the application of norepinephrine to prevent hypotension in general anesthesia, and the expected results can provide a scientific reference for the relevant research work.